(±)-Methoxyverapamil (hydrochloride) (Methoxyverapamil hydrochloride) 是 Verapamil 的甲氧基衍生物，是一种苯烷基胺钙拮抗剂。
| Cas No. | 16662-46-7 |
| 别名 | Methoxyverapamil hydrochloride |
| 化学名 | α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-benzeneacetonitrile, monohydrochloride |
| Canonical SMILES | COC1=C(OC)C=C(C(C(C)C)(C#N)CCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1OC.Cl |
| 分子式 | C28H40N2O5.HCl |
| 分子量 | 521.1 |
| 溶解度 | DMF: 16.7 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 0.25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (±)-Methoxyverapamil is a phenylalkylamine L-type calcium channel blocker and methoxy derivative of verapamil . (±)-Methoxyverapamil blocks recombinant rat L-type calcium channels expressed in tsA201 cells with IC50 values of 782 and 8,000 nM at holding potentials of 10 and -60 mV, respectively. It blocks maitotoxin-induced calcium influx in NIH3T3 fibroblasts (IC50 = 16 μM) and inhibits histamine-induced acid secretion by primary enriched guinea pig parietal cells (IC50 = 10.9 μM). (±)-Methoxyverapamil binds to rat myocardial membranes (IC50 = 16 nM) and inhibits electrically-stimulated contractions in rat right myocardial ventricular strips (EC50 = 1.95 μM). In conscious, ovariectomized, post-partum rats, it decreases blood pressure by 30 mm Hg and induces 60% inhibition of uterine contractions when administered at doses of 204 and 324 μg/kg, respectively. |
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