Camostat Mesilate

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Camostat Mesilate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

59721-29-8

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议
100mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	494.52
Cas No.	59721-29-8
Formula	C₂₀H₂₂N₄O₅·CH₄O₃S
Solubility	insoluble in EtOH; ≥160.6 mg/mL in DMSO; ≥32.15 mg/mL in H2O
Chemical Name	[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate;methanesulfonic acid
Canonical SMILES	CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

试验操作

Cell experiment:[1]
Cell lines	Rat primary hepatic stellate cells (HSCs)
Reaction Conditions	500 μmol/L camostat mesilate for 7 d incubation
Applications	Camostat mesilate (500 μmol/L) inhibited generation of transforming growth factor β (TGF-β) by suppressing plasmin activity and reduced the activity of TGF-β, which blockedin vitroactivation of HSCs.
Animal experiment:[1]
Animal models	Male Wistar rats
Dosage form	1 ~ 2 mg/g Diet
Applications	Camostat mesilate (1 ~ 2 mg/g of diet) markedly attenuated an increase in hepatic plasmin and TGF-β levels, HSC activation, and hepatic fibrosis without apparent systemic or local side effects in porcine serum-treated rats. Therefore, camostat mesilate prevented porcine serum-induced rat hepatic fibrosis via a profound reduction in TGF-β generation
Note	The technical data provided above is for reference only.
	References: 1. Okuno M, Akita K, Moriwaki H, et al. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology, 2001, 120(7): 1784-1800.