| CAS NO: | 959-24-0 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 200mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 308.82 |
| Cas No. | 959-24-0 |
| Formula | C12H21ClN2O3S |
| Solubility | ≥15.44 mg/mL in DMSO; ≥2.86 mg/mL in EtOH; ≥55.7 mg/mL in H2O |
| Chemical Name | N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride |
| Canonical SMILES | CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Sotalol hydrochloride是高效非选择性β-肾上腺素能受体拮抗剂.Sotalol也是钾离子通道的抑制剂,在HEK细胞系中的IC50值约为1.2 mM [1].
作为III类抗心律失常药物,在折返性心动过速的兔心脏模型体外实验中,Sotalol hydrochloride提高功能性不应期,而不降低传导速度.
体内试验中,在完整狗心脏的恒心房起搏期间,Sotalol hydrochloride延长心房和心室单相动作电位时程[2].另外,Sotalol是β-肾上腺素能受体阻断剂,通常用于AF(心房颤动)的心律控制治疗[3].
参考文献：
[1] Vormberge T1, Hoffmann M, Himmel H. Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40. Epub 2006 Apr 25.
[2] Claudel JP1, Touboul P. Sotalol: from "just another beta blocker" to "the prototype of class III antidysrhythmic compound".Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.
[3] Sicouri S1, Pourrier M, Gibson JK, Lynch JJ, Antzelevitch C. Comparison of electrophysiological and antiarrhythmic effects of vernakalant, ranolazine, and sotalol in canine pulmonary vein sleeve preparations. Heart Rhythm. 2012 Mar;9(3):422-9.
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