| CAS NO: | 31677-93-7 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 276.2 |
| Cas No. | 31677-93-7 |
| Formula | C13H19Cl2NO |
| Solubility | ≥12.85 mg/mL in DMSO; ≥21.57 mg/mL in H2O; ≥52.4 mg/mL in EtOH |
| Chemical Name | 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydrochloride |
| Canonical SMILES | CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Bupropion hydrochloride是去甲肾上腺素和多巴胺神经递质的双重高效抑制剂,IC50值分别为6.5 ± 0.6 μM和3.4 ± 0.4 μM [1].
Bupropion hydrochloride是一种氨基酮,作为非尼古丁以帮助戒烟.Bupropion hydrochloride也是经典的抗抑郁药,能够干扰去甲肾上腺素\血清素和多巴胺的摄取[2].此外,Bupropion hydrochloride能够降低多巴胺生物合成中的限速酶—酪氨酸羟化酶的表达[3].体外实验中,Bupropion hydrochloride能够显著降低SH-SY5Y细胞的活力.而且,Bupropion hydrochloride能选择性激活ER应激通路.此外,这些结果也表明Bupropion hydrochloride能通过JNK和ER应激导致caspase 3活化,从而诱导细胞死亡[2].
参考文献：
[1] Dr. R. M. Ferris*, H. L. White,B. R. Cooper, R. A. Maxwell, F. L. M. Tang,O. J. Beaman and A. Russell .Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrin). Drug Development Research Volume 1, Issue 1, pages 21–35, 1981
[2] Jang EH1, Park CS, Kang JH. Bupropion, an atypical antidepressant, induces endoplasmic reticulum stress and caspase-dependent cytotoxicity in SH-SY5Y cells. Toxicology. 2011 Jul 11;285(1-2):1-7.
[3] Nestler, E. J., McMahon, A., Sabban, E.L., Tallman, J.F., Duman, R.S., 1990. Chronicantidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus. Proc. Natl. Acad. Sci. U. S. A. 87, 7522–7526.
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