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Cyclohexanecarboxylicacid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cyclohexanecarboxylicacid图片
CAS NO:1241-87-8
包装:20mg
市场价:1533元

产品介绍
环己烷羧酸是一种有效的 NF-κB 抑制剂，对 p105 的 RH 结构域具有显着的结合亲和力，Ki 为 0.002 μM，结合能为 1.50 Kcal/mol。环己烷羧酸具有抗氧化应激能力。环己烷羧酸抑制 PD-1/PD-L1 相互作用。
Cas No.1241-87-8
别名环己烷羧酸
化学名1-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-3,4,5-trihydroxycyclohexane-1-carboxylic acid
Canonical SMILESC1C(C(C(CC1(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O)O
分子式C16H18O9
分子量354.31
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.002 μM and binding energy of 1.50 Kcal/mol[1]. 1-Caffeoylquinic acid has anti-oxidative stress ability[2]. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact[3].

References:
[1]. Khan MK, et al. Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacogn Mag. 2013 Jan;9(33):51-7.
[2]. Jiang Y, et al. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017 Jun 17;17(1):320.
[3]. Han Y, et al. PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy. Anal Biochem. 2018 Apr 15;547:52-56.