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Phenylpyropene A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenylpyropene A图片
CAS NO:189564-20-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Phenylpyropene A 是一种真菌代谢物,是一种有效的酰基辅酶 A:胆固醇酰基转移酶 (ACAT) 抑制剂,IC50 为 0.8 μM。
Cas No.189564-20-3
别名苯基吡喃菌素A
Canonical SMILESO=C1C2=C(O[C@@]([C@@H](OC(C)=O)C[C@]3([H])[C@]4(C)CC[C@H](OC(C)=O)[C@@]3(C)COC(C)=O)(C)[C@]4([H])[C@H]2O)C=C(C5=CC=CC=C5)O1
分子式C32H38O10
分子量582.6
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3

|1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of acyl-CoA: Cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J. Antibiot. (Tokyo) 55(11), 1004-1008 (2002).|2. Lee, S.W., Rho, M.C., Choi, J.H., et al. Inhibition of diacylglycerol acyltransferase by phenylpyropenes produced by Penicillium griseofulvum F1959. J. Microbiol. Biotechnol. 18(11), 1785-1788 (2008).|3. Horikoshi, R., Goto, K., Mitomi, M., et al. Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening. J. Antibiot. (Tokyo) 70(3), 272-276 (2017).