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Flavokawain B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flavokawain B图片
CAS NO:1775-97-9
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
Flavokawain B (Flavokavain B) 是一种从卡瓦卡瓦植物的根提取物中分离出来的查尔酮,是一种有效的细胞凋亡诱导剂,用于抑制各种癌细胞系的生长。 Flavokawain B (Flavokavain B) 显示出很强的抗血管生成活性。 Flavokawain B (Flavokavain B) 以极低且无毒的浓度抑制人脑内皮细胞 (HUVEC) 迁移和管形成。
Cas No.1775-97-9
别名黄卡瓦胡椒素B,Flavokavain B
Canonical SMILESCOC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1
分子式C17H16O4
分子量284.3
溶解度DMF: 30 mg/mL,DMSO: 50 mg/mL,Ethanol: 10 mg/mL
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 µM, respectively).