| Cas No. | 337349-54-9 |
| 别名 | 2-[[3,4,5,6,7,8-六氢-3-(4-甲氧基苯基)-4-氧代[1]苯并噻吩并[2,3-D]嘧啶-2-基]硫代]-乙腈 |
| Canonical SMILES | O=C(C(C(CCCC1)=C1S2)=C2N=C3SCC#N)N3C4=CC=C(OC)C=C4 |
| 分子式 | C19H17N3O2S2 |
| 分子量 | 383.5 |
| 溶解度 | DMSO: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM. |
m.cnreagent.com