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Sodium Phenylbutyrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sodium Phenylbutyrate图片
CAS NO:1716-12-7
包装与价格:
包装价格(元)
10mM (in 1mL H2O)电议
100mg电议
200mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt186.18
Cas No.1716-12-7
FormulaC10H11O2·Na
Solubility≥27.65 mg/mL in H2O; ≥50.9 mg/mL in EtOH with ultrasonic; ≥6.3 mg/mL in DMSO
Chemical Namesodium;4-phenylbutanoate
Canonical SMILESC1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Sodium Phenylbutyrate is a histone deacetylase (HDAC) inhibitor [1].

HDAC, negatively regulating acetylation of histones, plays an important role in acetylation homeostasis which is a major epigenetic mechanism in cancer development and heart dysfunction [1].

In oral squamous cell carcinoma (OSCC) cell lines CAL27, HSC3, and SCC4, a series of doses of Sodium Phenylbutyrate including 1, 2, 4, 8, and 16 mM, inhibited all cell lines in a dose dependent manner, with IC50 values of 4.091, 3.712, and 3.015 mM, respectively. In HSC3 and SCC4 cells treated with 4 or 3 mM Sodium Phenylbutyrate for 12, 48, and 72 h, significant inhibition on cell vitality could be observed in a time dependent manner [2].

In a mouse model with Adriamycin-induced cardiac injury, Sodium Phenylbutyrate (400 mg/kg/day) was i.p. injected one day before and daily after the Adriamycin injection for two days. Sodium Phenylbutyrate substantially reversed the Adriamycin-induced elevation of creatine kinase and serum lactase dehydrogenase activities, and meanwhile, diminished Adriamycin-induced ultrastructual damages of cardiac tissue by more than 70%. In addition, Sodium Phenylbutyrate completely rescued Adriamycin-associated reduction of cardiac functions, and increased cardiac manganese superoxide dismutase (MnSOD) protein and activity [1].

References:

[1]. Daosukho C, Chen Y, Noel T, et al. Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury. Free Radical Biology and Medicine, 2007, 42(12): 1818-1825.

[2]. Qian K, Sun L, Zhou G, et al. Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo. Cancer Biotherapy and Radiopharmaceuticals, 2018, 33(4): 139-145.