PDD00017273

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PDD00017273

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1945950-21-9

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
5mg	电议
10mg	电议
25mg	电议

产品介绍

化学性质

Storage	Store at -20°C
M.Wt	514.62
Cas No.	1945950-21-9
Formula	C₂₃H₂₆N₆O₄S₂
Solubility	≥50mg/ml in DMSO
Chemical Name	1-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-N-(1-methylcyclopropyl)-3-((2-methylthiazol-5-yl)methyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
Canonical SMILES	O=C(N(CC1=CN=C(C)S1)C(N2CC3=CC(C)=NN3C)=O)C4=C2C=CC(S(NC5(CC5)C)(=O)=O)=C4
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with IC50 of 26 nM and KD value of 1.45 nM. PDD00017273 is 350 times more selective for PARG on a series of ion channels, enzymes and receptors including PARP1 and ARH3.PDD 00017273 (10 μM) does not inhibit five common Cytochrome P450 enzymes. PDD 00017273 (30 μM) modestly increasess phosphorylated H2AX (γH2AX) intensity.PDD 00017273 also decreases in NAD/H activity through PARG inhibition after DNA damage.