化学性质
| Storage | Store at -20°C |
| M.Wt | 459.54 |
| Cas No. | 1234479-76-5 |
| Formula | C25H29N7O2 |
| Solubility | ≥100mg/ml in DMSO |
| Chemical Name | 2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one |
| Canonical SMILES | CN(C1=CN=C(NC2=C(OC)C=C(N3CCN(C)CC3)C=C2)N=C1N(C)C4=C5C=CC=C4)C5=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
ERK5-IN-1 is a potent and selective ERK5 inhibitor. In vitro, ERK5-IN-1 effectively inhibits ERK5 biochemically with an IC50 of 162 nM. In cell experiments, ERK5-IN-1 has a cellular EC50 for inhibiting epidermal growth factor induced ERK5 autophosphorylation of 0.09 μM. In cell-based analysis, it is at least 30 times more selective for ERK5 than LRRK2. It is also ERK5 selective for a group of other kinases. Available Oral Bioavailability.
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