Taurolithocholic Acid (sodium salt) 是一种有效的胆汁抑制剂，是一种有效的 Ca2+ 激动剂。
| Cas No. | 6042-32-6 |
| 别名 | 牛磺石胆酸钠 |
| Canonical SMILES | O=C(NCCS([O-])(=O)=O)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+] |
| 分子式 | C26H44NO5S•Na |
| 分子量 | 505.7 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acid . TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells. It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis. Serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans. |
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