| 包装 | 价格(元) |
| 100mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 5g | 电议 |
Sodium oxamate as PDK1 and LDHA inhibitor with IC50 values (μg/mL) of 15.60.
Cell lines | BRCA ovarian cancer cells:A2780 and SKOV3 |
Preparation Method | Cell proliferation is evaluated using a Cell Counting Kit-8. SKOV3 cells and A2780 cells are seeded in a 96-well culture plates at a density of 2 105 cells/well and incubated with different concentrations of the drugs for different times(Sodium oxamate). |
Reaction Conditions | 50 mM Sodium oxamate for 24 h |
Applications | Sodium oxamate enhances the suppressive effects of PARP inhibitors on ovarian cancer without BRCA mutations, remarkably promoting the inhibitory effects of PARP inhibitors on wild-type BRCA ovarian cancer cells. |
Animal models | Four-week-old male BALB/c nude mice of CRC xenograft |
Preparation Method | C. tropicalis was given by multipoint intratumoral injection, twice per week for three weeks.Oxaliplatin (10 mg/kg) and Sodium oxamate (500 mg/kg) were administered by intraperitoneal injection, twice per week for three weeks. The length and width of the tumors were measured every three days. |
Dosage form | 500 mg/kg Sodium oxamate Twice a week for three weeks |
Applications | Sodium oxamate reduces the growth of colorectal cancer in CRC mice, by restoring the down-regulated MMR functional proteins and attenuating chemotherapy resistance to oxaliplatin caused by C. tropicalis. |
| 产品描述 | Sodium oxamate as PDK1 and LDHA inhibitor with IC50values (μg/mL) of 15.60[1]. Sodium oxamate can specifically inhibit LDH-A. Sodium oxamate by down-regulating CDK1/cyclin B1 Pathway induces G2/M cell cycle arrest and promotes apoptotic targets by increasing ROS production in mitochondria[4,5]. Sodium oxamate enhances the suppressive effects of PARP inhibitors on ovarian cancer without BRCA mutations, remarkably promoting the inhibitory effects of PARP inhibitors on wild-type BRCA ovarian cancer cells[3]. In the human PC cell line, Sodium oxamate caused cell inhibition, resulting in increased sensitivity of CRPC cells to DOC, and the combination of DOC and Sodium oxamate promoted apoptosis compared with DOC or Sodium oxamate alone[2]. Sodium oxamate reduces the growth of colorectal cancer in CRC mice, by restoring the down-regulated MMR functional proteins and attenuating chemotherapy resistance to oxaliplatin caused by C. tropicalis[6]. NETosis and lactate accumulation during LPS induced sepsis in mice was inhibited by sodium oxamate[7]. References: |
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