Siramesine is an agonist of the sigma-2 (σ2) receptor (IC50 = 0.19 nM).
| Cas No. | 163630-79-3 |
| Canonical SMILES | FC(C=C1)=CC=C1N2C=C(CCCCN3CCC4(C(C=CC=C5)=C5CO4)CC3)C6=C2C=CC=C6.OC(/C=C/C(O)=O)=O |
| 分子式 | C30H31FN2O•C4H4O4 |
| 分子量 | 570.7 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Siramesine is an agonist of the sigma-2 (σ2) receptor (IC50 = 0.19 nM). It is selective for σ2 over σ1 (IC50 = 17 nM) and related receptors and transporters. Siramesine is anxiolytic without inducing sedation or impairing motor coordination in animal studies. It is known to induce the death of cancer cells in vitro by destabilizing lysosomes, although it has also been shown to destabilize mitochondria and, with lapatinib , induce ferroptosis. |
m.cnreagent.com