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Sancycline(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sancycline(hydrochloride)图片
CAS NO:6625-20-3
包装与价格：
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
 
Cas No.6625-20-3
别名二甲胺四环素杂质B
Canonical SMILESO=C1C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@](C3=C(O)[C@@]21O)([H])CC4=CC=CC(O)=C4C3=O.Cl
分子式C21H22N2O7.HCl
分子量450.9
溶解度DMF: 20mg/mL,DMSO: 20mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.15 mg/mL,Ethanol: 5mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sancycline is a semi-synthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively).1,2 Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml.3 In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

References
1. McCormick, J.R.D., Jensen, E.R., Miller, P.A., et al. The 6-deoxytetracyclines. Further studies on the relationship between structure and antibacterial activity in the tetracycline series. J. Am. Chem. Soc. 82(13), 3381-3386 (1960).
2. Wexler, H.M., Molitoris, E., and Finegold, S.M. In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria. Antimicrob. Agents Chemother. 38(10), 2513-2515 (1994).
3. Testa, R.T., Perterson, P.J., Jacobus, N.V., et al. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Antimicrob. Agents Chemother. 37(11), 2270-2277 (1993).