| CAS NO: | 204656-20-2 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 3751.20 |
| Cas No. | 204656-20-2 |
| Formula | C172H265N43O51 |
| Solubility | insoluble in EtOH; insoluble in DMSO; insoluble in H2O; ≥3.85 mg/mL in Acetic acid：H2O：DMSO=1:1:1 |
| Canonical SMILES | CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCCCC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC( |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Liraglutide is a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist [1].
GLP-1R, mainly expressed on the pancreatic β cells, is the receptor of glucagon like peptide-1 (GLP-1) which plays an important role in glucose-stimulated insulin release and the preservation of plasma glucose homeostasis. GLP-1R is also expressed on vascular endothelial cells, with potential roles in vascular biology [1].
In human umbilical vein endothelial cell line C11-STH20, liraglutide at 100 nM attenuated induction of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) expression. In addition, liraglutide also rendered protection against endothelial cell dysfunction, an early abnormality in diabetic vascular disease.
In the ApoE-/- mouse model, liraglutide (300 μg/kg, b.i.d., s.c.) significantly inhibited GLP-1R-dependent endothelial cell dysfunction. Furthermore, liraglutide treatment also induced endothelial nitric oxide synthase (eNOS) expression while reduced intercellular adhesion molecule-1 (ICAM-1) expression in aortic endothelium. The above effects were again abrogated by the concomitant administration of a GLP-1R antagonist [1].
Reference:
[1]. Gaspari T, Liu H, Welungoda I, et al. A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model. Diabetes & Vascular Disease Research, 2011, 8(2): 117-124.
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