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Ethacrynic acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ethacrynic acid图片
CAS NO:58-54-8
包装与价格：
包装价格(元)
1g电议
5g电议
10g电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt303.14
Cas No.58-54-8
FormulaC13H12Cl2O4
SynonymsMK 595,NSC 85791,NSC 624008
Solubilityinsoluble in H2O; ≥15.15 mg/mL in DMSO; ≥44.4 mg/mL in EtOH
Chemical Name2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetic acid
Canonical SMILESO=C(O)COC1=CC=C(C(C(CC)=C)=O)C(Cl)=C1Cl
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Ethacrynic acid is one of the most used loop diuretics, acting by inhibiting NKCC2 which is specifically found in the thick ascending loop of Henle in the kidneys. Inhibition of NKCC2 significantly increases the concentrations of Na+, K+, and Cl–in the tubule, and reduces hypertonicity in the surrounding interstitium, causing less water to be reabsorbed into the blood. Eventually, more urine will be produced and excreted, and a decrease in blood volume can be achieved. Loop diuretics have been used for the treatment of fluid overload/edema in congestive heart failure, acute pulmonary edema, nephrotic syndrome, hepatic ascites, renal failure, as well as other edematous disorders.

References:

1. Vardanyan R, Hruby V. Synthesis of Best-Seller Drugs. Chapter 21 - Diuretics, 2016, 317-327.

2. Zins GR, Walk RA, Gussin RZ, et al. The diuretic activity of ethacrynic acid in rats. Journal of Pharmacology and Experimental Therapeutics, 1968, 163(1): 210-215.

试验操作

Animal experiment:[2]

Animal models

Rats

Dosage form

37.5 and 125 mg/kg

Intravenous administration

Applications

Single doses of 37.5 and 125 mg/kg increased water and potassium excretion 2-fold, sodium excretion 3-fold and chloride excretion 4-fold in relation to parallel control animals. Single dose activity was confined to the 1st hr after injection whereas effects persisted for the duration of observation when animals were primed with 25 mg/kg and sustained with 50 mg/kg/hr.

Note

The technical data provided above is for reference only.

References:

1. Vardanyan R, Hruby V. Synthesis of Best-Seller Drugs. Chapter 21 - Diuretics, 2016, 317-327.

2. Zins GR, Walk RA, Gussin RZ, et al. The diuretic activity of ethacrynic acid in rats. Journal of Pharmacology and Experimental Therapeutics, 1968, 163(1): 210-215.