| CAS NO: | 1850293-95-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 311.2 |
| Cas No. | 1850293-95-6 |
| Formula | C12H12N2O3Se |
| Synonyms | Selenium-acetylsalicylic Acid |
| Solubility | ≤10mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide |
| Chemical Name | selenocyanic acid, 2-[[2-(acetyloxy)benzoyl]amino]ethyl ester |
| Canonical SMILES | O=C(C)OC1=CC=CC=C1C(NCC[Se]C#N)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Se-Aspirin is a novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID) [1].
NSAIDs have demonstrated intestinal antineoplastic effects in various animal intestinal cancer models. Selenium (Se) compounds have attracted a vast interest as promising chemo-preventive agents. Several epidemiological studies have reported an inverse association between the nutritional Se status and cancer risk. Se functioned as chemo-preventive agent for cancer therapy in the past few years.
Se-Aspirin was a hybrid of selenium and a nonsteroidal anti-inflammatory drug. t Se-Aspirin reduced the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells with the IC50 value of 3.4 μM. Se-Aspirin inhibited the cell cycle in G1 and G2/M phases and induced apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin has been reported to cause an increase in intracellular reactive oxygen species levels in CRC cells [1].
Reference:
[1] Plano D, Karelia D N, Pandey M K, et al. Design, synthesis, and biological evaluation of novel selenium (Se-NSAID) molecules as anticancer agents[J]. Journal of medicinal chemistry, 2016, 59(5): 1946-1959.
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