nor-NOHA(acetate)

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nor-NOHA(acetate)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1140844-63-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A lyophilized powder
Storage	Store at -20°C
M.Wt	296.3
Cas No.	1140844-63-8
Formula	C₅H₁₂N₄O₃·2C₂H₄O₂
Synonyms	Nω-hydroxy-nor-Arginine
Solubility	≤5mg/ml in DMSO;1mg/ml in dimethyl formamide
Chemical Name	2S-amino-4-[[(hydroxyamino)iminomethyl]amino]-butanoic acid, diacetate
Canonical SMILES	N/C(N([H])CC[C@H](N)C(O)=O)=N\O.CC(O)=O.CC(O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Ki: 0.5 μM for rat liver arginase

nor-NOHA is a potent and reversible inhibitor of rat liver arginase.

L-Arginine is a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS an catalyze the oxidation of arginine to citrulline and NO. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine.

In vitro: Previous study found that nor-NOHA could inhibit the proliferation and induce the apoptosis of HepG2 cells. nor-NOHA was also able to decrease the expression levels of Arg1 and MMP-2, increase the expression levels of P53 and ECD as well as the production of NO. In addition, nor-NOHA inhibited the invasion and migration of HepG2 cells. These data indicated that nor-NOHA could induce cell apoptosis and inhibit the ability of invasion and migration of HepG2 cells by inhibiting Arg1 [1].

In vivo: Animal study showd that nor-NOHA treatment could fully restore the aortic response to Ach to that of healthy rats. The results also showed that such beneficial effect was mediated by an increase in NOS activity and EDHF and reduced superoxide anion production. In addition, nor-NOHA could decrease IL-6 and VEGF plasma levels in AIA rats. Whereas, the treatment did not modify arthritis severity in AIA rats [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Li X, Zhu F, He Y, Luo F. Arginase inhibitor nor-NOHA induces apoptosis and inhibits invasion and migration of HepG2 cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Apr;33(4):477-482.
[2] Prati C, Berthelot A, Kantelip B, Wendling D, Demougeot C. Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis. Arthritis Res Ther. 2012 May 30;14(3):R130.