| CAS NO: | 20004-62-0 |
| 包装: | 1mg |
| 市场价: | 2618元 |
| Physical Appearance | A powder |
| Storage | Store at -20°C |
| M.Wt | 376.4 |
| Cas No. | 20004-62-0 |
| Formula | C22H16O6 |
| Synonyms | Antibiotic A-3733A,Heliomycin |
| Solubility | Soluble in DMSO;dimethyl formamide |
| Chemical Name | 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2H-benzo[cf]pyrene-2,6(1H)-dione |
| Canonical SMILES | O=C1C(C)(C)C2=C3C4=C(C(O)=CC(C)=C4C(O)=C2)C(C5=C(O)C=C(O)C1=C53)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Resistomycin is a natural antibiotic.
Resistomycin is a natural antibiotic produced by several actinobacteriae, such as Streptomyces.
In vitro: Resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of Streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of Hypericum perforatum L. as modulators for apoptosis. In human megakaryoblastic leukemia CMK-7 cells, resistomycin could inhibit apoptosis induced by actinomycin D (AD) with or without acceleration by colcemid (CL), IC50 for inhibition against AD-induced apoptosis was about 0.5 μM and IC50 for inhibition against AD plus CL-induced apoptosis was about 1 μM. CL alone induced weak apoptosis in cells, which could be enhanced by resistomycin. Moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. In addition, PKC in CMK-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Shiono, Y. ,Shiono, N.,Seo, S., et al. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z. Naturforsch. C. 57(9-10), 923-929 (2002).
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