| CAS NO: | 66-71-7 |
| 包装 | 价格(元) |
| 5g | 电议 |
| 10g | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 180.21 |
| Cas No. | 66-71-7 |
| Formula | C12H8N2 |
| Solubility | insoluble in H2O; ≥360.42 mg/mL in DMSO; ≥58.9 mg/mL in EtOH |
| Chemical Name | 1,10-phenanthroline |
| Canonical SMILES | C(C=CC=N1)(C=C2)=C1C3=C2C=CC=N3 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
O-Phenanthroline is a membrane-permeable metal chelator, known as a non-specific matrix metalloproteinase (MMP) inhibitor [1].
Matrix metalloproteinases (MMPs) are zinc-dependent proteases involved in intra- and extra-cellular matrix remodeling resulting from an oxidative stress injury to the heart, of which MMP-2 increases during myocardial ischemia-reperfusion (I/R) injury-reduced oxidative stress, proteolyzing nuclear structural proteins.
Invitro proteolysis of lamins, which are the intermediate filament proteins providing support to the nuclear structural proteins and are targets of MMP-2,o-Phenanthroline abolished the proteolysis of lamin A [2].
The isolated rat hearts were subjected to ischemia-reperfusion (I/R) injury, of which treated witho-Phenanthroline had better left ventricular developed pressure and coronary flow during the reperfusion phase compared to those did not receive the drug [2].
Reference:
[1] Georgi N, Landman E B M, Klein T J, et al.O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models [J]. J Tissue Eng Regen Med. 2017, 11(3): 724-732.
[2] Baghirova S, Hughes B G, Poirier M, et al. Nuclear matrix metalloproteinase-2 in the cardiomyocyte and the ischemic-reperfused heart [J]. J Mol Cell Cardiol. 2016, 94: 153-161.
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