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Ubiquitin Isopeptidase Inhibitor I
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ubiquitin Isopeptidase Inhibitor I图片
CAS NO:108477-18-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt414.4
Cas No.108477-18-5
FormulaC19H14N2O7S
SynonymsNSC 144303
Solubility≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
Chemical Nametetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide
Canonical SMILESO=C(/C(CS(C/1)(=O)=O)=C\C2=CC=C([N+]([O-])=O)C=C2)C1=C/C3=CC=C([N+]([O-])=O)C=C3
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

IC50: ~30 μM

Ubiquitin Isopeptidase Inhibitor I is a ubiquitin isopeptidase inhibitor.

Conjugation or deconjugation of ubiquitin or ubiquitin-like proteins to or from cellular proteins is a multifaceted and universal ways of regulating cellular physiology, controlling the lifetime, localization, and activity of various key proteins.

In vitro: Ubiquitin Isopeptidase Inhibitor I targeted the ubiquitinproteasome system via inhibiting the ubiquitin isopeptidases. Ubiquitin Isopeptidase Inhibitor I could induce a rather unique apoptotic pathway, including a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. Moreover, the treatment of Ubiquitin Isopeptidase Inhibitor I to cell extracts obtained from E1A cells did not inhibit the proteolytic activity of the proteasome, whereas MG-132 potently inhibited the cleavage of the LLVY-AMC substrate. In addition, Noxa induction by Ubiquitin Isopeptidase Inhibitor I could be inhibited by the specific RNAi oligos efficiently. When apoptosis was scored, it was found that down-regulation of Noxa was able to inhibit but did not suppress apoptosis and caspase activation in response to Ubiquitin Isopeptidase Inhibitor I treatment [1].

In vivo: So far, there is no animal in vivo data reported.

Clinical trial: Up to now, Ubiquitin Isopeptidase Inhibitor I is still in the preclinical development stage.

Reference:
[1] E.  Aleo, C. J. Henderson, A. Fontanini, et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Research 66(18), 9235-9244 (2006).