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Z-Ligustilide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Z-Ligustilide图片
CAS NO:81944-09-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Z-藁本内酯是从川芎中提取的,具有抗菌和抗真菌活性,平均抗真菌评分为 5.6。
Cas No.81944-09-4
别名藁本内酯
化学名(3Z)-3-butylidene-4,5-dihydro-2-benzofuran-1-one
Canonical SMILESCCCC=C1C2=C(C=CCC2)C(=O)O1
分子式C12H14O2
分子量190.23
溶解度≥ 16.45mg/mL in DMSO
储存条件-20°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 2.27 and 4.78 μM against L1210 and K562 cell lines

Z-Ligustilide, isolated and purified from the essential oil of A. sinensis. Z-Ligustilide has been reported to facilitate blood circulation and attenuate inflammatory pain behavior.

In vitro: Previous results showed pretreatment with Z-Ligustilide (LIG) improved cell viability significantly. The apoptosis rate in glutamate-induced PC12 cells decreased in the presence of LIG. Western blot results indicated that LIG could decrease the release of Cyt C from mitochondria, up-regulate Bcl-2/Bax ratio and down-regulate Caspase-3 protein expression, resulting in protecting PC12 cells from apoptosis [1].

In vivo: In ovariectomized (OVX) osteopenic rats, the anti-inflammatory potential of LIG was determined by ELISA. LIG was found to be able to inhibit OVX-induced up-regulation of NF-κB activation and the production of TNF-α, iNOS, IL-1β, ICAM-1 and COX-2 significantly. In addition, LIG could suppress MDA and PMN infiltration. The significant anti-inflammatory effect of Z-Ligustilide in experimental OVX osteopenic rats clearly demonstrated that there might be an inflammatory component in the etiology of osteoporosis [2].

Clinical trial: N/A

References:
[1] Wu Q,Wang N,Wang Y,Wang GY,Piao XX.  rotective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao.2015 Feb;50(2):162-8.
[2] Ma Z,Bai L.  The anti-inflammatory effect of Z-Ligustilide in experimental ovariectomized osteopenic rats. Inflammation.2012 Dec;35(6):1793-7.