您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > 2F-Peracetyl-Fucose
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
2F-Peracetyl-Fucose
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2F-Peracetyl-Fucose图片
CAS NO:188783-78-0
包装与价格：
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍
2F-Peracetyl-Fucose (1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos) 是一种有效的岩藻糖基转移酶 (FUT) 抑制剂。
Cas No.188783-78-0
别名2,6-二脱氧-2-氟-L-吡喃半乳糖三乙酸酯,1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucopyranos
Canonical SMILESO=C(C)O[C@@H]([C@H]([C@@H]1F)OC(C)=O)[C@@H](OC1OC(C)=O)C
分子式C12H17FO7
分子量292.3
溶解度Chloroform: soluble,Methanol: soluble,DMSO: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2F-Peracetyl-fucose is an inhibitor of protein fucosylation.[1] It inhibits fucosylation of IgG1 monoclonal antibodies produced by CHO-DG44 cells when used at a concentration of 50 &#181M. It reduces intracellular GDP-fucose levels in CHO-DG44 cells in a concentration-dependent manner. 2F-Peracetyl-fucose (100 &#181M) also decreases intracellular fucose levels in A. thaliana seedlings.[2] 2F-Peracetyl-fucose decreases root length in A. thaliana seedlings in a concentration-dependent manner.

Reference:
[1].Okeley, N.M., Alley, S.C., Anderson, M.E., et al.Development of orally active inhibitors of protein and cellular fucosylationProc. Natl. Acad. Sci. USA110(14)5404-5409(2013)
[2].Villalobos, J.A., Yi, B.R., and Wallace, I.S.2-Fluoro-L-fucose is a metabolically incorporated inhibitor of plant cell wall polysaccharide fucosylationPLoS One10(9)e0139091(2015)