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Acepromazine(maleate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Acepromazine(maleate)图片
CAS NO:3598-37-6
包装与价格：
包装价格(元)
10mg电议
50mg电议
100mg电议
250mg电议

产品介绍
 
Cas No.3598-37-6
别名乙酰丙嗪马来酸酯,Acetopromazine maleate; Acetylpromazine maleate
Canonical SMILESCN(C)CCCN1C2=C(C=CC(C(C)=O)=C2)SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O
分子式C19H22N2OS.C4H4O4
分子量442.5
溶解度DMF: 1mg/mL,DMSO: 3mg/mL,Ethanol: 2mg/mL,PBS (pH 7.2): 2mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine , and a dopamine receptor antagonist.1 It also binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine .2 Acepromazine inhibits morphine-induced vomiting in dogs.3 It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively).4 Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.

References
1. Monteiro, E.R., Teixeira Neto, F.J., Castro, V.B., et al. Effects of acepromazine on the cardiovascular actions of dopamine in anesthetized dogs. Vet. Anaesth. Analg. 34(5), 312-321 (2007).
2. Fjalland, B., Christensen, A.V., and Hyttel, J. Peripheral and central muscarinic receptor affinity of psychotropic drugs. Naunyn. Schmiedebergs. Arch. Pharmacol. 301(1), 5-9 (1977).
3. Koh, R.B., Isaza, N., Xie, H., et al. Effects of maropitant, acepromazine, and electroacupuncture on vomiting associated with administration of morphine in dogs. J. Am. Vet. Med. Assoc. 244(7), 820-829 (2014).
4. J., A. Pharmacological specificity of conditioned avoidance response inhibition in rats: Inhibition by neuroleptics and correlation to dopamine receptor blockade. Acta. Pharmacol. Toxicol. (Copenh). 51(4), 321-329 (1982).