CAS NO: | 946572-73-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Cas No. | 946572-73-2 |
别名 | Coniferyl (E)-8-methyl-6-nonenoate |
化学名 | 8-methyl-6E-nonenoic acid 3-(4-hydroxy-3-methoxyphenyl)-2E-propen-1-yl ester |
Canonical SMILES | COC1=C(O)C=CC(/C=C/COC(CCCC/C=C/C(C)C)=O)=C1 |
分子式 | C20H28O4 |
分子量 | 332.4 |
溶解度 | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | EC50: 3.2 μM for TRPV1 Capsiconiate is a TRPV1 agonist. The capsaicin receptor, also termed as transient receptor potential vanilloid type 1 (TRPV1), is an non-selective cation, calcium permeable channel. The activation of TRPV1 has been reported to contribute to the various physiological activities of capsaicin. In vitro: Capsiconiate was isolated from the fruits of the pepper, Capsicum baccatum L. var. praetermissum. The agonist activity of the capsiconiate for TRPV1 was evaluated by conducting an analysis of the intracellular calcium concentrations in TRPV1-expressing HEK293 cells. The EC50 value of capsiconiate was determined to be 3.2 microM. However, the activity was weaker than that of capsaicinor capsiate. It was found that capsiconiate had no pungency, and therefore, the low activity could be explained on the basis of the structure-activity relationship. The instability capsiconiate in aqueous solvents might also be responsible for its low activity. Even though the agonist activity for TRPV1 was lower than that of capsaicin, its activity was comparable with that of other naturally occurring compounds such as gingerol, piperine, and capsaicinol [1]. In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted. Reference: |