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Capsiconiate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Capsiconiate图片
CAS NO:946572-73-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.946572-73-2
别名Coniferyl (E)-8-methyl-6-nonenoate
化学名8-methyl-6E-nonenoic acid 3-(4-hydroxy-3-methoxyphenyl)-2E-propen-1-yl ester
Canonical SMILESCOC1=C(O)C=CC(/C=C/COC(CCCC/C=C/C(C)C)=O)=C1
分子式C20H28O4
分子量332.4
溶解度≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

EC50: 3.2 μM for TRPV1

Capsiconiate is a TRPV1 agonist.

The capsaicin receptor, also termed as transient receptor potential vanilloid type 1 (TRPV1), is an non-selective cation, calcium permeable channel. The activation of TRPV1 has been reported to contribute to the various physiological activities of capsaicin.

In vitro: Capsiconiate was isolated from the fruits of the pepper, Capsicum baccatum L. var. praetermissum. The agonist activity of the capsiconiate for TRPV1 was evaluated by conducting an analysis of the intracellular calcium concentrations in TRPV1-expressing HEK293 cells. The EC50 value of capsiconiate was determined to be 3.2 microM. However, the activity was weaker than that of capsaicinor capsiate. It was found that capsiconiate had no pungency, and therefore, the low activity could be explained on the basis of the structure-activity relationship. The instability capsiconiate in aqueous solvents might also be responsible for its low activity. Even though the agonist activity for TRPV1 was lower than that of capsaicin, its activity was comparable with that of other naturally occurring compounds such as gingerol, piperine, and capsaicinol [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Kobata, K. ,Tate, H.,Iwasaki, Y., et al. Isolation of coniferyl esters from Capsicum baccatum L., and their enzymatic preparation and agonist activity for TRPV1. Phytochemistry 69(5), 1179-1184 (2008).