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Ethyl 3-Aminobenzoate(methanesulfonate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ethyl 3-Aminobenzoate(methanesulfonate)图片
CAS NO:886-86-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
25g电议
50g电议
100g电议

产品介绍
3-氨基苯甲酸乙酯（甲磺酸）（MS-222）通常用于固定鱼以进行标记或运输，以及在侵入性手术过程中抑制感觉系统。
Cas No.886-86-2
别名3-氨基苯甲酸乙酯甲基磺酸盐,Ethyl m-Aminobenzoate, NSC 93790, Tricaine methanesulfonate , MS-222
化学名3-amino-benzoic acid-ethyl ester, monomethanesulfonate
Canonical SMILESO=C(OCC)C1=CC(N)=CC=C1.O=S(O)(C)=O
分子式C9H11NO2o CH4O3S
分子量261.3
溶解度≥ 13.25mg/mL in DMSO
储存条件Store at 2-8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ethyl 3-Aminobenzoate can block the generation of action potentials via voltage-dependent Na+-channels.

Sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. Sodium channels are also of special importance for the history of physiology.

In vitro: The major mode of action for ethyl 3-aminobenzoate was found to be nervous system suppression whereby the entrance of sodium into the nerve was inhibited, therefore limiting nerve membrane excitability. In addition, the nerve inhibition was facilitated by the lipid solubility of ethyl 3-aminobenzoate, which allowed it to move easily into the cell membrane to bind with sodium channels [1].

In vivo: Previous study evaluated the potency and dynamics of ethyl 3-aminobenzoate-induced effects on neuronal firing of sensory and motor nerves alongside a defined motor behavior in Xenopus laevis tadpoles. Electrophysiological recordings of extraocular motor discharge and nerve activity were measured before, during and after administration of drugs. Results showed that ethyl 3-aminobenzoate and benzocaine, but not pancuronium could cause a dose-dependent, reversible blockade of extraocular motor and sensory nerve activity. Such results indicated that ethyl 3-aminobenzoate was able to block the activity of both sensory and motor nerves compatible with the mechanistic action of effective anesthetics, suggesting that ethyl 3-aminobenzoate was effective as single-drug anesthetic for surgical interventions in anamniotes [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] K.  M. Carter, C. M. Woodley and R. S. Brown. A review of tricaine methanesulfonate for anesthesia of fish. Rev. Fish Biol. Fisheries 21, 51-59 (2011).
[2] C.  Ramlochansingh, F. Branoner, B. P. Chagnaud, et al. Efficacy of tricaine methanesulfonate (MS-222) as an anesthetic agent for blocking sensory-motor responses in Xenopus laevis tadpoles. PLoS One 9(7), e101606 (2014).