| CAS NO: | 9072-19-9 |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | N/A |
| Cas No. | 9072-19-9 |
| Formula | (C6H9O3SO3)n |
| Synonyms | Fucan,Sulfated α-L-Fucan |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥8.5 mg/mL in DMSO |
| Chemical Name | (2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate |
| Canonical SMILES | C[C@@H]1O[C@@](C)([H])[C@@H](OC)[C@H](O)[C@@H]1OS(O)(=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Fucoidan, a type of complex carbohydrate called a polysaccrharide, is found in many forms of brown seaweed. Fucoidan has a variety of biological activities, including anticancer, antiviral, neuroprotective, and immune-modulating effects. It has been reported that fucoidan enhances the activities of natural killer (NK) cells which play a vital role in anti-cancer activity.
In vitro: Fucoidan triggered apoptosis of PC-3 cells, human prostate cancer cells, via evoking intrinsic and extrinsic signaling pathways in a dose-dependent fashion, which indicated that fucoidan could dose-dependently block the growth of PC-3 cells. The activation of apoptosis induced by fucoidan was involved in the inactivation of p38 MAPK and phosphatidylinositol 3-kinase (PI3K) /Akt, and the activation of extracellular signal-regulated kinase mitogen-activated protein kinase (ERK1/2 MAPK) [1].
In vivo: Female Balb/c mice bearing breast cancer were intraperitoneally injected with fucoidan at 10 mg/kg body weight every two days for 20 days. Fucoidan decreased the tumor volume and the tumor weight in Balb/c mice. Additionally, fucoidan triggered apoptosis, which indicated that fucoidan could exert a strong antitumor effect on breast cancer model. Compared with control group, fucoidan dampened angiogenesis in tumor tissue via inducing a remarkable decrease in intratumoral vascular endothelial growth factor expression and inhibited lung metastasis of breast cancer [2].
References:
[1]. Boo, H., Hong, J., Kim, S., Kang, J., Kim, M., & Kim, E. et al. The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells. Marine Drugs. 2013; 11(8): 2982-2999.
[2]. Xue, M., Ge, Y., Zhang, J., Wang, Q., Hou, L., & Liu, Y. et al. Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo. Plos ONE. 2012; 7(8). e43483.
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