| CAS NO: | 118675-50-6 |
| 包装 | 价格(元) |
| 1mg (solution) | 电议 |
| 5mg (solution) | 电议 |
| 10mg (solution) | 电议 |
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 459.6 |
| Cas No. | 118675-50-6 |
| Formula | C25H37N3O5 |
| Solubility | ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| Chemical Name | 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid |
| Canonical SMILES | O=C1C(CCCCCCC(O)=O)N(NCC(O)C2CCCCC2)C(N1CC3=CC=CC=C3)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
BW A868C is a novel, selective and potent competitive antagonist of prostaglandin D2 (PGD2) [1].
Prostaglandin D2 has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system [2]. Prostaglandin D2 is critical for the development of allergic diseases such as asthma.
In vitro: In glycerol-lysed human platelets, BW245C activated adenylate cyclase in a biphasic manner. BW A868C showed no effect on carbacyclin, iloprost, prostacyclin, PGE1 and PGE2 at a concentration 1,000 fold that of its KB against PGD2 and BW245C [1]. BW A868C showed no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki value for BW A868C is approximately 1.7 nM[1] .In isolated rings of rabbit saphenous vein (RbSV) pre-contracted with 40 mM KCl, BW245C caused concentration-dependent relaxations with an EC50 of 38 nM [3].
References:
[1] Giles H, Leff P, Bolofo M L, et al. The classification of prostaglandin DP‐
eceptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist[J]. British journal of pharmacology, 1989, 96(2): 291-300.
[2] Shimizu T, Mizuno N, Amano T, et al. Prostaglandin D2, a neuromodulator[J]. Proceedings of the National Academy of Sciences, 1979, 76(12): 6231-6234.
[3] Lydford S J, McKechnie K C W, Leff P. Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein[J]. Prostaglandins, 1996, 52(2): 125-139.
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