| CAS NO: | 30034-03-8 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 484.5 |
| Cas No. | 30034-03-8 |
| Formula | C18H17N6O5S2·Na |
| Synonyms | Cephamandole |
| Solubility | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Chemical Name | (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt |
| Canonical SMILES | O=C(N[C@@H]1C(N2[C@]1([H])SCC(CSC3=NN=NN3C)=C2C([O-])=O)=O)[C@H](O)C4=CC=CC=C4.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
MIC: 0.25-2 mg/L for different E. coli strains
Cefamandole is a cephalosporin antibiotic.
The cephalosporins are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".
In vitro: The in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. Against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. None of the Pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].
In vivo: The testicular toxicity of cefamandole was evaluated in neonatal rats. Results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. In rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].
Clinical trial: A randomized, single-blind comparison of parenteral cefamandole and ampicillin was conducted in adult patients with pneumonia or purulent tracheobronchitis. Results showed that cefamandole was as effective and safe as ampicillin. Of the 14 patients treated with cefamandole, 13 were considered cured, as were 12 of the 13 treated with ampicillin [3].
References:
[1] Eickhoff TC, Ehret JM. In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. Antimicrob Agents Chemother. 1976 Jun;9(6):994-9.
[2] Hoover DM, Buening MK, Tamura RN, Steinberger E. Effects of cefamandole on spermatogenic development of young CD rats. Fundam Appl Toxicol. 1989 Nov;13(4):737-46.
[3] Delgado DG, Brau CJ, Cobbs CG, Dismukes WE. Clinical and laboratory evaluation of cefamandole in the therapy of Haemophilus spp. Bronchopulmonary infections. Antimicrob Agents Chemother. 1979 Jun;15(6):807-12.
m.cnreagent.com