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N1-Acetylspermidine(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N1-Acetylspermidine(hydrochloride)图片
CAS NO:34450-16-3
包装与价格：
包装价格(元)
10mM (in 1mL Water)电议
5mg电议
10mg电议

产品介绍
N1-乙酰亚精胺（盐酸盐）是多胺的乙酰基衍生物。 N1-乙酰精胺是多胺氧化酶 (PAO) 的底物。 N1-Acetylspermidine (hydrochloride) 选择性地提高其在人类结直肠腺癌中的水平。 N1-乙酰亚精胺在 DNA 中的脱嘌呤位点显示出切割效率。
Cas No.34450-16-3
别名N-乙酰精脒盐酸盐
Canonical SMILESCC(NCCCNCCCCN)=O.Cl.Cl
分子式C9H21N3O.2HCl
分子量260.2
溶解度DMSO: 0.1 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N1-Acetylspermidine is an acetyl derivative of spermidine that acts as a substrate for polyamine oxidase (PAO).1 In peroxisomes, PAO oxidizes N1-acetylspermidine to 3-acetamidopropanal and putrescine, a positively charged polyamine that binds DNA and is involved in various cellular processes including cell division, differentiation, and membrane function.2,3,4,5 N1-Acetylspermidine has been used to examine the interaction between DNA and polyamines during the cleavage of phosphodiester bonds at apurinic/apyrimidinic sites in DNA.6

References
1. Takao, K., Sugita, Y., and Shirahata, A. Assay of N1-acetylpolyamine oxidase activity with N1,N11-didansylnorspermine as the substrate by ion-pair reversed phase high performance liquid chromatography. Biological and Pharmaceutical Bullentin 33(7), 1089-1094 (2010).
2. Gawandi, V., and Fitzpatrick, P.F. The synthesis of deuterium-labeled spermine, N1-acetylspermine and N1-acetylspermidine. Journal of Labelled Compounds and Radiopharmaceuticals 50(7), 666-670 (2007).
3. Gill, S.S., and Tuteja, N. Polyamines and abiotic stress tolerance in plants. Plant Signal. Behav. 5(1), 26-33 (2010).
4. Prunotto, M., Compagnone, A., Bruschi, M., et al. Endocellular polyamine availability modulates epithelial-to-mesenchymal transtition and unfolded protein response in MDCK cells. Lab Invest. 90(6), 929-939 (2010).
5. Babbar, N., Ignatenko, N.A., Casero, R.A., Jr., et al. Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. The Journal of Biological Chemisty 278(48), 47762-47775 (2003).
6. Haukanes, B.I., Szajko, K., and Helland, D.E. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. FEBS Letters 269(2), 389-393 (1990).