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Glycolithocholic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Glycolithocholic Acid图片
CAS NO:474-74-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Glycolithocholic acid 是一种内源性代谢物，是一种与甘氨酸结合的次级胆汁酸。
Cas No.474-74-8
别名甘氨石胆酸,Lithocholylglycine
化学名N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]-glycine
Canonical SMILESC[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式C26H43NO4
分子量433.6
溶解度20mg/mL in ethanol & DMSO, 30mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glycolithocholic acid is a glycine-conjugated form of the secondary bile acid lithocholic acid.[1] It is increased in livers of mice that are fed diets supplemented with ursodeoxycholic acid.[2] Glycolithocholic acid levels are decreased in lean mice treated with obestatin.[3] Serum glycolithocholic acid levels increase with age in children.[4]

Reference:
[1]. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89(1), 147-191 (2009).
[2]. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem. 66(3), 507-514 (1976).
[3]. Cowan, E., Kimar, P., Burch, K.J., et al. Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics. Metabolomics 12(124), (2016).
[4]. Semba, R.D., Gonzalez-Freier, M., Moaddel, R., et al. Environmental enteric dysfunction is associated with altered bile acid metabolism. J. Pediatr. Gastenterol. Nutr. 64(4), 536-540 (2017).

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