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UNC-1999
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UNC-1999图片
CAS NO:1431612-23-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
UNC 1999, UNC1999
产品介绍

生物活性

UNC-1999是生物可利用抑制剂,对野生型和突变型ezh2以及ezh1具有高体外效力,无细胞试验中IC50分别为2 nM和45 nM,对广泛表观遗传学相关或不相关的靶点选择性大于1000倍。

靶点信息

EZH2 (Cell-free assay)EZH1 (Cell-free assay)
2 nM45 nM

化学数据

目录号A13166
作用机制Inhibitor (抑制剂)
M. Wt569.74
FormulaC33H43N7O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1431612-23-5
SynonymsUNC 1999, UNC1999
SMILESCCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C

溶解度

In vitroDMSO17 mg/mL (29.84 mM)
WaterInsoluble
Ethanol43 mg/mL (75.47 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.55 mL87.76 mL175.52 mL
0.5 mM3.51 mL17.55 mL35.1 mL
1 mM1.76 mL8.78 mL17.55 mL
5 mM0.35 mL1.76 mL3.51 mL

*The above data is based on the productmolecular weight 569.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.