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Benzyl butyl phthalate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Benzyl butyl phthalate图片
CAS NO:85-68-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议

产品介绍
Benzylbutylphthalate是邻苯二甲酸酯(PAEs)的一员，通过上调Zeb1的表达，可引起血管瘤(HA)细胞的迁移和侵袭。Benzylbutylphthalate激活乳腺癌细胞中的芳香烃受体(AhR)，刺激SPHK1/S1P/S1PR3信号传导，促进转移性乳腺癌干细胞(BCSCs)的形成。
Cas No.85-68-7
别名邻苯二甲酸丁苄酯
Canonical SMILESO=C(C1=CC=CC=C1C(OCC2=CC=CC=C2)=O)OCCCC
分子式C19H20O4
分子量312.36
溶解度DMSO: 100 mg/mL (320.14 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[1][2][3].

Benzyl butyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity[1].Benzyl butyl phthalate induces histone modifications in S1PR3 in side population (SP) cells, but not in non-SP cells[3].

[1]. Sun G, et al. Developmental toxicity and cardiac effects of butyl benzyl phthalate in zebrafish embryos. Aquat Toxicol. 2017;192:165-170. [2]. Cui S, et al. Benzyl butyl phthalate (BBP) triggers the migration and invasion of hemangioma cells via upregulation of Zeb1. Toxicol In Vitro. 2019;60:323-329. [3]. Wang YC, et al. Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling. Oncotarget. 2016;7(20):29563-29576.