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Vemurafenib(PLX4032 RG7204 RO5185426)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vemurafenib(PLX4032 RG7204 RO5185426)图片
CAS NO:918504-65-1
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)489.92
FormulaC23H18ClF2N3O3S
CAS No.918504-65-1; 918505-61-0 (vemurafenib analog)
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 97 mg/mL (198.0 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL
Solubility (In vivo)4% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5 mg/mL
Synonym

Vemurafenib; RO5185426; RG7204; PLX 4032; RG 7204; RO 5185426; RG-7204; RO5185426; PLX4032; PLX-4032; trade name: Zelboraf

Chemical Name: N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

实验参考方法
GeneralABT-199 (100 mg/kg) causes a maximal tumor growth inhibition of 95% and tumor growth delay of 152% in RS4;11 xenografts.
Animal modelMice (athymic nude) xenograft models of LOX, Colo829, and A375 cells
FormulationFormulated as microprecipitated bulk powder (MBP), suspended at the desired concentration in an aqueous vehicle containing 2% Klucel LF, and adjusted to pH 4 with dilute HCl
Dosages12.5 mg/kg–100 mg/kg
AdministrationOral gavage twice a day
Reference[1] Yang H, et al. Cancer Res, 2010, 70(13), 5518-5527.
生物活性


Mol Cancer Ther; 15(8); 1859–69, 2016