L-Glutathione Reduced

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

70-18-8

包装与价格：

包装	价格(元)
10mM (in 1mL H2O)	电议
5g	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	307.32
Cas No.	70-18-8
Formula	C₁₀H₁₇N₃O₆S
Solubility	insoluble in EtOH; insoluble in DMSO; ≥14.25 mg/mL in H2O
Chemical Name	(S)-2-amino-5-(((R)-1-((carboxymethyl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-5-oxopentanoic acid
Canonical SMILES	SC[C@@H](C(NCC(O)=O)=O)NC(CC[C@@H](C(O)=O)N)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

L-Glutathione Reduced is an endogenous antioxidant, with the ability to scavenge oxygen-derived free radicals. L-Glutathione Reduced is a non-protein thiol widely present in living cells, which plays an important role in a series of biological events, including protein and DNA synthesis, enzyme activity, metabolism as well as cell protection. Not only does L-Glutathione Reduced scavenge oxygen-derived free radicals which contribute to the development of many common diseases including cancer, heart attack, stroke, arthritis, but it also helps in regenerating other antioxidants such as vitamin E and ascorbic acid. Thus, L-Glutathione Reduced is established to be a marker of oxidative stress. In addition, L-Glutathione Reduced is used for eluting glutathione S-transferase (GST) from glutathione agarose.

Reference:

1. Pereira-Rodrigues N, Cofré R, Zagal JH, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry, 2007, 70(1): 147-154.

试验操作

动物实验 [1]：
动物模型	雄性甲状腺功能低下Wistar 大鼠
剂量	0.0012%，口服
应用	与对照组相比，甲状腺功能减退症大鼠的肝脏和心脏组织中脂质过氧化和维生素E的速率均未观察到显着影响，而甲状腺功能亢进大鼠的甲状腺功能明显增强。
注意事项	请测试所有化合物在室内的溶解度，实际溶解度和理论值可能略有不同，这是由实验系统的误差引起的，属于正常现象。
References: [1]. Messarah M, Boulakoud MS, Boumendjel A, Abdennour C, El Feki A. The impact of thyroid activity variations on some oxidizing-stress parameters in rats. C R Biol. 2007 Feb;330(2):107-12. Epub 2006 Dec 12. PubMed PMID: 17303537.