Gadolinium chloride

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Gadolinium chloride

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

10138-52-0

包装与价格：

包装	价格(元)
10mM (in 1mL H2O)	电议
50mg	电议

产品介绍

化学性质

Physical Appearance	A solid
Storage	Desiccate at RT
M.Wt	263.61
Cas No.	10138-52-0
Formula	GdCl₃
Solubility	≥11.04 mg/mL in DMSO; ≥2.03 mg/mL in EtOH with gentle warming and ultrasonic; ≥9.85 mg/mL in H2O
Chemical Name	gadolinium(III) chloride
Canonical SMILES	Cl[Gd](Cl)Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Gadolinium chloride is a CaSR agonist. The CaSR can activate the NLRP3 inflammasome by increasing intracellular Ca²⁺and decreasing cellular cyclic AMP. Thus, CaSR agonists may serve as a useful tool for exploring NLRP3 inflammasome associated inflammatory diseases such as cryopyrin-associated periodic syndromes, gout and atherosclerosis. In addition, gadolinium chloride has been demonstrated to block TRPML channel currents, as well as other transient receptor potential (TRP) channels.

References:

1. Lee GS, Subramanian N, Kim AI, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca²⁺and cAMP. Nature, 2012, 492(7427): 123-127.

2. Nagata K, Zheng L, Madathany T, et al. The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(1): 353-358.

3. Del Favero G, Florio C, Codan B, et al. The stretch-activated channel blocker Gd³⁺reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chemical Research in Toxicology, 2012, 25(9): 1912-1920.

试验操作

Cell experiment:[3]
Cell lines	Skeletal muscle cells
Reaction Conditions	100 μM gadolinium chloride for 30min or 1 h incubation
Applications	Gadolinium chloride significantly reduced the cytotoxicity of palytoxin by blocking stretch-activated calcium channels, with a 30% increase in cell survival after up to 1 h of exposure to 1 nM palytoxin.
Note	The technical data provided above is for reference only.
	References: 1. Lee GS, Subramanian N, Kim AI, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012, 492(7427): 123-127. 2. Nagata K, Zheng L, Madathany T, et al. The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(1): 353-358. 3. Del Favero G, Florio C, Codan B, et al. The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chemical Research in Toxicology, 2012, 25(9): 1912-1920.