| CAS NO: | 28822-58-4 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 222.24 |
| Cas No. | 28822-58-4 |
| Formula | C10H14N4O2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥9.45 mg/mL in DMSO |
| Chemical Name | 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione |
| Canonical SMILES | O=C(N(C)C1=O)N(C2=C1NC=N2)CC(C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
IBMX is a widely-used non-specific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively[1].
By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists[2].
Sprague–Dawley rats receive an i.c.v. injection(IBMX or saline) 10 min before receiving an i.p. injectionof cocaine or saline. Intracerebroventricular IBMX does not affect the acute hyperlocomotor responseto cocaine, but when coadministered with cocaine for 7 consecutive days, attenuated development ofbehavioral sensitization. These results suggest that IBMX inhibition of PDE-mediated adenosine production[3].
References:
[1]. Wu BN, et al. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol, 2004, 142(7): 1105-14.
[2]. Snyder S H, Katims J J, Annau Z, et al. Adenosine receptors and behavioral actions of methylxanthines. Proc. Natl. Acad. Sci. USA, 1981, 78(5): 3260-3264.
[3]. Schroeder J A, Ruta J D, Gordon J S, et al. The phosphodiesterase inhibitor isobutylmethylxanthine attenuates behavioral sensitization to cocaine. Behavioural Pharmacology, 2012, 23(3): 310-314.
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