| CAS NO: | 582323-16-8 |
| 包装: | 50mg |
| 市场价: | 4967元 |
| Cas No. | 582323-16-8 |
| 化学名 | (Z)-N-(2-chloropyrimidin-5-yl)-3,4-difluorobenzimidic acid |
| Canonical SMILES | ClC1=NC=C(/N=C(O)/C2=CC(F)=C(F)C=C2)C=N1 |
| 分子式 | C11H6ClF2N3O |
| 分子量 | 269.63 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ICA-069673 is a KCNQ2/Q3 potassium channel activator with an IC50 of 0.69 μM. ICA-069673 is found to be 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5 and has no measurable activity against a panel of cardiac ion channels (IC50 values >30 μM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels at 10 μM[1]. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, an 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3. Based on ICA73 sensitivity of chimeric constructs of the transmembrane segments of KCNQ2 and KCNQ3, this drug appears to interact with the KCNQ2 voltage sensor (S1-S4)[2]. References: |
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