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Ralfinamide mesylate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ralfinamide mesylate图片
CAS NO:202825-45-4
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
Ralfinamide mesylate (FCE-26742A mesylate) 是一种来自 α-氨基酰胺的口服 Na+ 通道阻滞剂，具有抑制疼痛的作用。
Cas No.202825-45-4
别名(S)-2-((4-((2-氟苄基)氧基)苄基)-氨基)丙酰胺甲烷磺酸酯,FCE-26742A mesylate
化学名(S)-2-((4-((2-fluorobenzyl)oxy)benzyl)amino)propanamide methanesulfonate
Canonical SMILESOS(=O)(C)=O.FC1=CC=CC=C1COC2=CC=C(C=C2)CN[C@H](C(N)=O)C
分子式C17H19FN2O2.CH3SO3H
分子量398.45
溶解度<9.96mg/ml in Water;<39.84mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain[1][2].

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain[1].

References:
[1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305.
[2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34.