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TCS 5861528
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TCS 5861528图片
CAS NO:332117-28-9
包装与价格：
包装价格(元)
10mg电议
50mg电议
500mg电议
1g电议

产品介绍
TCS 5861528 (TCS 5861528) 是一种有效的 TRPA1 通道拮抗剂，可拮抗类似的异硫氰酸烯丙酯和 4-HNE 诱发的 TRPA1 反应，IC50 值分别为 14.3 μM 和 18.7 μM。
Cas No.332117-28-9
别名TCS 5861528
化学名(R)-N-(4-(sec-butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide
Canonical SMILESO=C1N(C)C(N(C)C(N=C2)=C1N2CC(NC3=CC=C(C=C3)[C@H](C)CC)=O)=O
分子式C19H23N5O3
分子量369.42
溶解度≥ 76 mg/mL in DMSO with ultrasonic and warming, ≥ 6.17 mg/mL in EtOH with ultrasonic and warming
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

References:
[1]. Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54.
[2]. Wei H, et al. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 2010 Mar;58(3):578-84.
[3]. Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.