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CCMI
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CCMI图片
CAS NO:917837-54-8
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
CCMI (AVL-3288) 是一种有效且选择性的 α7 nAChR 阳性变构调节剂，不通过正构位点结合或激活 α7 nAChRs，并导致激动剂诱导的 α7 nAChRs 电流显着正向调节。
Cas No.917837-54-8
别名AVL-3288; UCI-4083
化学名(Z)-N-(4-chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide
Canonical SMILESClC1=CC=C(C=C1)NC(/C(C2=CC(C)=NO2)=C\NC(C=C3)=CC=C3Cl)=O
分子式C19H15Cl2N3O2
分子量388.25
溶解度<38.83mg/ml in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].

References:
[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.