Relatlimab

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Relatlimab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1673516-98-7

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

Relatlimab (BMS-986016) 是一种人单克隆抗体抗 LAG-3 抗体，由携带重组 LAG-3 蛋白的人免疫球蛋白的转基因小鼠免疫生成。Relatlimb 阻断了 LAG-3/MHC II 的相互作用，其 IC50 值为 0.67 nM，以及阻断了 LAG-3/FGL1 的相互作用，其 IC50 值为 0.019 nM。Relatlimab 可用于癌症的研究。

Cas No.	1673516-98-7
别名	BMS-986016
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Relatlimab (BMS-986016) is a human monoclonal antibodyanti-LAG-3antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with anIC₅₀value of 0.67 nM and LAG-3/FGL1 interaction with anIC₅₀value of 0.019 nM. Relatlimab can be used in research of cancer^[1]. Relatlimab (BMS-986016; 0.001-100 nM) recognizes native LAG-3 and binds to primary activated human and cynomolgus CD4+ T cells with EC₅₀values of 0.11 nM and 29.11 nM, respectively^[1]. Relatlimab (0.001-10000 nM; T cells (3A9-hLAG-3)) enhances peptide responsiveness of T-cell hybridoma 3A9-hLAG-3 and reversals LAG-3-mediated inhibition of T-cell hybridoma 3A9-hLAG-3 with an IC₅₀value of 1.05 nM^[1]. Relatlimab (0.001-10000 nM; primary T cells) enhances activation of superantigen-stimulated human PBMC cultures and enhances IL-2 secretion^[1].