您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > Aminooxy-PEG2-azide
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Aminooxy-PEG2-azide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Aminooxy-PEG2-azide图片
CAS NO:1043426-13-6
包装与价格：
包装价格(元)
50mg电议
100mg电议
250mg电议

产品介绍
Aminooxy-PEG2-azide 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。Aminooxy-PEG2-azide 也是一种不可降解 (non-cleavable) 的含 2 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。
Cas No.1043426-13-6
分子式C6H14N4O3
分子量190.2
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aminooxy-PEG2-azide is a PEG-basedPROTAC linkerthat can be used in the synthesis of PROTACs[1]. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEGADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].