CAS NO: | 50-78-2 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
1g | 电议 |
5g | 电议 |
Storage | Store at -20°C |
M.Wt | 180.16 |
Cas No. | 50-78-2 |
Formula | C9H8O4 |
Synonyms | 2-Acetoxybenzoic acid, Acylpyrin, Ecotrin, Acenterine, Polopiryna, Acetosal |
Solubility | insoluble in H2O; ≥104.2 mg/mL in EtOH with ultrasonic; ≥8.55 mg/mL in DMSO |
Chemical Name | 2-acetyloxybenzoic acid |
Canonical SMILES | CC(=O)OC1=CC=CC=C1C(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
阿司匹林(乙酰水杨酸)是一种有效的环氧化酶(COX)抑制剂,具有广谱的药理活性,包括抗炎和镇痛。多个研究积累了关于服用阿司匹林与降低癌症风险关系的充足证据,包括前列腺癌、乳腺癌、大肠癌、子宫内膜癌和卵巢癌。阿司匹林可充当组蛋白去乙酰化酶的抑制剂,上调细胞周期停滞蛋白p21,抑制携带COX-1的卵巢癌细胞。阿司匹林也能够在人类脐静脉内皮细胞和新生大鼠心肌细胞中抑制COX-2表达,从而分别导致PG生成减少和ERK与NF-KB下调。
参考文献:
Cho M, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013;4(8):671-678.
Duan Y, Chen F, Zhang A, Zhu B, Sun J, Xie Q, Chen Z. Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. BMB Rep. 2013. pii: 2320. [Epub ahead of print]
Cell experiment:[1] | |
Cell lines | Porcine alveolar macrophages |
Reaction Conditions | 3 mM aspirin for 30 min pretreatment |
Applications | Aspirin inhibited lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. |
Animal experiment:[2] | |
Animal models | Male albino Charles River rats weighing between 200 and 250 g |
Dosage form | 5, 25, 50, 100 and 150 mg/kg Administered orally |
Applications | Aspirin, administered orally at 5, 25, 50 and 100 mg/kg, exhibited antipyretic activity at all doses. The ED50 values calculated from these data ranged from 10.3 to 21.1 mg/kg. In addition, statistically significant antipyresis was demonstrated 15 min after an oral dose of 150 mg/kg of aspirin, with the maximum effect occurred at 120 min. |
Note | The technical data provided above is for reference only. |
References: 1. Duan Y, Chen F, Zhang A, et al. Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. BMB Reports, 2014, 47(1): 45-50. 2. Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicology and Applied Pharmacology, 1972, 22(4): 672-675. |