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Succinyl phosphonate trisodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Succinyl phosphonate trisodium salt图片
CAS NO:864167-45-3
包装与价格：
包装价格(元)
2mg电议
5mg电议
10mg电议

产品介绍
Succinyl phosphonate trisodium salt (SP) 琥珀酰膦酸三钠盐是 α-酮戊二酸脱氢酶 (KGDHC ) 抑制剂，可有效抑制肌肉，细菌，脑和人成纤维细胞中的 KGDHC。Succinyl phosphonate trisodium salt (SP) 抑制 2-氧代戊二酸脱氢酶 (OGDH)，以细胞特异性代谢依赖性方式损害癌细胞的活力。Succinyl phosphonate trisodium salt (SP) 抑制谷氨酸诱导的谷氨酸刺激的海马神经元中的 ROS 产生。
Cas No.864167-45-3
别名琥珀酰膦酸盐
Canonical SMILESO=C(O[Na])CCC(P(O[Na])(O[Na])=O)=O
分子式C4H4Na3O6P
分子量248.01
溶解度Water: 125 mg/mL (504.01 mM)
储存条件Store at 4℃, sealed storage, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Succinyl phosphonate trisodium salt (SP) is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4].Succinyl phosphonate trisodium salt (SP) is an 2-Oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2].Succinyl phosphonate trisodium salt (SP) inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3].

[1]. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. [2]. Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21. [3]. ZÜndorf G, et al. alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ. Neuroscience. 2009 Jan 23;158(2):610-6. [4]. Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61.