CAS NO: | 1998725-11-3 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 1998725-11-3 |
Canonical SMILES | O=C(OCC)[C@H](CCC(C=[N+]=[N-])=O)NC([C@H](CC(C)C)N)=O |
分子式 | C14H24N4O4 |
分子量 | 312.36 |
溶解度 | DMSO: 100 mg/mL (320.14 mM) |
储存条件 | Store at -20℃, protect from light, stored under nitrogen |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2]. Glutamine[2] [1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033. |