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JHU-083
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JHU-083图片
CAS NO:1998725-11-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
JHU-083 选择性地阻断脑 CD11b+ 细胞中的谷氨酰胺酶 (glutaminase) 活性。谷氨酰胺拮抗剂 JHU-083 在实验性脑疟疾 (ECM) 中可阻断谷氨酰胺酶,导致动物中谷氨酸水平的净降低。
Cas No.1998725-11-3
Canonical SMILESO=C(OCC)[C@H](CCC(C=[N+]=[N-])=O)NC([C@H](CC(C)C)N)=O
分子式C14H24N4O4
分子量312.36
溶解度DMSO: 100 mg/mL (320.14 mM)
储存条件Store at -20℃, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2]. Glutamine[2]

[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.