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Tangeretin(Tangeritin NSC53909)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tangeretin(Tangeritin NSC53909)图片
CAS NO:481-53-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)372.37
FormulaC20H20O7
CAS No.481-53-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 8 mg/mL (21.5 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILESO=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
SynonymsTangeritin; NSC-53909; NSC-618905; NSC 53909; NSC 618905; NSC53909; NSC618905
实验参考方法
In Vitro

In vitro activity: Tangeretin is a polymethoxylated flavonoid concentrated in the peel of citrus fruits. Recent studies have shown that tangeretin exhibits anti-proliferative, anti-invasive, anti-metastatic, and antioxidant activities. Tangeretin at 2.7 μM induces apoptosis in human promyelocytic leukaemia HL-60 cells, whereas the flavone showed no cytotoxicity against human peripheral blood mononuclear cells (PBMCs). Further study shows that tangeretin at 50 μM exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins such as Cdk2 and Cdk4, and mediates the increase of Cdk inhibitors p21 and p27. Pretreatment with tangeretin inhibites IL-1beta-induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB in human lung epithelial carcinoma cells (A549) and and human non-small cell lung carcinoma cells (H1299).


Cell Assay: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion

In VivoIn this study, the in vivo anti-RSV activity of tangeretin was investigated in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice.
Animal modelMice
Formulation & DosageN/A
References

Br J Cancer. 1995 Dec;72(6):1380-8; Carcinogenesis. 2002 Oct;23(10):1677-84; J Agric Food Chem. 2015 Nov 4;63(43):9520-7.