| CAS NO: | 86390-77-4 |
| 包装 | 价格(元) |
| 10mg (solution) | 电议 |
| 25mg (solution) | 电议 |
| 50mg (solution) | 电议 |
| 100mg (solution) | 电议 |
| Physical Appearance | A solution in acetonitrile. To change the solvent, simply evaporate the acetonitrile under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 398.58 |
| Cas No. | 86390-77-4 |
| Formula | C23H42O5 |
| Solubility | ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| Chemical Name | (S)-2-acetoxy-3-hydroxypropyl oleate |
| Canonical SMILES | CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(C)=O)CO)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
1-Oleoyl-2-acetyl-sn-glycerol is a synthetic activator of protein kinase C (PKC) [1].
PKC is a member of protein kinase enzymes which are involved in regulating the functions of other proteins via the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC plays a key role in intracellular signal transduction of Ca2+-dependent effects [2].
In the clonal GH3 line of anterior pituitary cells, 1-oleoyl-2-acetyl-sn-glycerol at 4 ~ 60 μM reversibly reduced Ca2+ currents produced by test potentials to 10 mV, with IC50 value ~ 25 μM. 1-Oleoyl-2-acetyl-sn-glycerol at above concentrations also inhibited Ca2+ currents in chick embryo dorsal root ganglion cells and clonal AtT-20 pituitary cells [1]. In isolated rat parietal cells, 10-7 ~ 10-5 mol/l 1-oleoyl-2-acetyl-sn-glycerol reduced the submaximal and maximal H+ production response to 10-5 or 10-4 mol/l carbachol [2]. In human podocytes expressing transient receptor potential canonical-6 (TRPC6) channels, 100 μM 1-oleoyl-2-acetyl-sn-glycerol markedly increased intracellular Ca2+ levels of the cells via TRPC6 channels [3].
References:
[1]. Marchetti C, Brown AM. Protein kinase activator 1-oleoyl-2-acetyl-sn-glycerol inhibits two types of calcium currents in GH3 cells. American Journal of Physiology, 1988, 254(1 Pt 1): C206-C210.
[2]. Schepp W, Brosch E, Tatge C, et al. Cholinergic stimulation of isolated rat parietal cells: role of calcium, calmodulin and protein kinase C. Clinical Physiology and Biochemistry, 1989, 7(3-4): 137-148.
[3]. Ambrus L, Oláh A, Oláh T, et al. Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes. Journal of Cellular and Molecular Medicine, 2015, 19(12): 2771-2779.
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