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AZD 3147
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD 3147图片
CAS NO:1101810-02-9
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
AZD 3147 是一种有效的、具有口服活性的、选择性的 mTORC1 和 mTORC2 双重抑制剂,IC50 值为 1.5 nM。 AZD 3147 对 PI3K 也有选择性作用。
Cas No.1101810-02-9
化学名N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)-thiourea
Canonical SMILESS=C(NCCO)NC(C=C1)=CC=C1C2=NC(C3(CC3)S(C4CC4)(=O)=O)=CC(N5CCOC[C@@H]5C)=N2
分子式C24H31N5O4S2
分子量517.7
溶解度1mg/mL in ethanol, 100mM in DMSO, 100nM in hydrochloride acid
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AZD 3147 is an orally bioavailable dual inhibitor of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2 (IC50s = 40.7 and 5.75 nM, respectively, in MDA-MB-468 cells).[1] It is selective for mTOR over PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ (IC50s = 1.51, 912, 5,495, 9,333, and 6,310 nM, respectively, in enzyme assays).

Reference:
[1]. Pike, K.G., Morris, J., Ruston, L., et al. Discovery of AZD3147: A potent, selective dual inhibitor of mTORC1 and mTORC2. J. Med. Chem. 58(5), 2326-2349 (2015).
AZD 3147