CAS NO: | 1101810-02-9 |
包装 | 价格(元) |
500μg | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 1101810-02-9 |
化学名 | N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)-thiourea |
Canonical SMILES | S=C(NCCO)NC(C=C1)=CC=C1C2=NC(C3(CC3)S(C4CC4)(=O)=O)=CC(N5CCOC[C@@H]5C)=N2 |
分子式 | C24H31N5O4S2 |
分子量 | 517.7 |
溶解度 | 1mg/mL in ethanol, 100mM in DMSO, 100nM in hydrochloride acid |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | AZD 3147 is an orally bioavailable dual inhibitor of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2 (IC50s = 40.7 and 5.75 nM, respectively, in MDA-MB-468 cells).[1] It is selective for mTOR over PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ (IC50s = 1.51, 912, 5,495, 9,333, and 6,310 nM, respectively, in enzyme assays). Reference: |